Dr. Lloyd Caswell Kelly, pastor of the Pineville First Baptist Church, founded Clear Creek in 1926. His mission for bringing Christian education to the mountains was two-fold. He was inspired to charter Clear Creek Mountain Springs, Inc., "… for educational, recreational and religious purposes, with two objectives in mind: (1) to provide grounds for assemblies and encampments and (2) to establish a base for a ‘mountain mission’ program." The first sessions for preachers were held July 18 — August 1, 1926 with twelve students.
In 1946, the General Association of Baptists in Kentucky (now the Kentucky Baptist Convention) approved the name of the school as Clear Creek Mountain Preacher’s Bible School. The primary focus of the school continued to be educating God-called men and women for Christian ministry.

From 1954-1982, Dr. Dennis Merrill Aldridge served as the second president of the school. Under his leadership, the school grew to offer a four-year baccalaureate degree. A charter revision in 1957 changed the name to Clear Creek Baptist School.

From 1982-1988, Dr. Leon Dennis Simpson was president. He led the school to receive accreditation from the Accrediting Associations of Bible Colleges in 1986, at which time the name was changed to Clear Creek Baptist Bible College.

Dr. Bill D. Whittaker served as president of the college from 1988 to 2007. Early in his administration, the college became debt free. In 1996, the Accrediting Association of Bible Colleges reaffirmed the college’s accreditation for ten more years. A successful capital campaign concluded in 1998 with the completion of a new classroom building and nearly a million dollars in additional endowment. In June 1999, the college received accreditation with the Commission on Colleges of the Southern Association of Colleges and Schools.

On April 17, 2007, the trustees of Clear Creek Baptist Bible College voted unanimously to call Dr. Donnie Fox as the school’s fifth president. An alumnus of the Pineville college, Dr. Fox has served as Director of College Relations, Director of Admissions, and most recently as Dean of Institutional Advancement. Dr. Fox holds a Bachelor of Arts in Ministry degree from Clear Creek Baptist Bible College, a Master of Divinity from Southern Baptist Theological Seminary, and a Doctor of Education also from Southern Seminary.